The Mangosteen Pericarp
Pericarp, which is the rind or peel, contains the highest level of xanthones.
The pulp, which is the fruit, known for being one of the tastiest
fruits in the world. The seeds found in the pulp. Mangosteen has
compounds that have antioxidant, anti-bacterial, anti-fungal, and
anti-tumor activity. Laboratory tests have indicated that extracts
of mangosteen have activity against several cancer cell lines
including breast, liver, and leukemia. Mangosteen also contains
anti-histamine and anti-inflammatory properties. Mangosteen has been
used for many years as a medicinal treatment for diarrhea, skin
infection and wounds in South Asia.
The latest in scientific research
shows mangosteen contains a class of naturally occurring
polyphenolic compound known as xanthones. Xanthones provide
beneficial effects on cardiovascular diseases, including ischemic
heart disease, atherosclerosis, hypertension, and thrombosis.
Mangosteen shows vasorelaxant properties. Mycobacterium
tuberculosis, Staphylococcus aureus, Mangosteen has shown inhibitory
action against these organisms. Mangosteen is highly effective in
weak immune system. There are several compounds found in the
Mangosteen that appear to make this fruit so active as a nutritional
component for the body.
Mangosteen Xanthones
are broken down even further into mangostin, mangostenol,
mangostenone A, Mangostenone B, trapezifolixanthone, tovophyllin B,
alpha- and beta-mangostins, garcinone B, mangostinone, mangostanol
and the flavonoid epicatechin. A study of the antiproliferation,
antioxidation and induction of apoptosis by Garcinia mangostana on
SKBR3 human breast cancer cell line, showed SKBR3 cells were
cultured in the presence of mangosteen extract at various
concentrations. Mangosteen showed a dose dependent inhibition of
cell proliferation. We found that an antiproliferative effect of
mangosteen was associated with apoptosis on breast cancer cell line
by determinations of morphological changes and oligonucleosomal DNA
fragments. Mangosteen also was found to inhibit ROS production.
These investigations suggest that the mangosteen had strong
anti-proliferation, potent anti-oxidation and induction of
apoptosis. Mangosteen has potential for cancer chemoprevention,
which is dose dependent as well as exposure time dependent. The
ethanol extract of Mangosteen showed potent inhibitory activity
against HIV-1 protease. The activity-guided purification of the
extract resulted in the isolation of two active known compounds. The
chemical structures of the isolated compounds were established by
spectroscopic analysis as mangostin and gamma-mangostin.
Potential Benefits of
Mangosteen
• Anti-viral
• Anti-bacterial
• Free radical fighter
• Cardio support
• Immune system Enhancer
• Powerful antioxidant
• Skin rashes, infections and wounds
• Diarrhea
• Anti-inflammatory
• VasorelaxantMangosteen RX contains:
100% Pure Xanthones Rich
Mangosteen Pericarp (hull powder) - No
Fillers, No Additives, No Preservatives, No Artificial Colors.
Gelatin capsule.
References and Studies:
Tapiero, H., et. al. “Polyphenols: do
they play a role in the prevention of human pathologies?”
Biomedicine & Pharmacotheraphy; 2002, 56 (4):200-207
Huang, D., et. al. “High-throughout
assay of oxygen radical absorbency capacity using multichannel
liquid handling system coupled with a microplate florescence reader
in 96 we format.” Journal of Agricultural and Food Chemistry: 2002
50 (16): 4437-4444
Mangosteen in the Columbia
Encyclopedia, 6 th edition, Columbia University Press 2003
Parkinson. R. “Mangoes, Lychees and
Mangosteen.: Chinese Cuisine 2004
Nakatani, K. , et. al.
“gamma-Mangostin inhibits IkappaB Kinase Activity with and decreases
Lipopolysaccaride-induced cyclooxgenanase-2 Gene Expression in C6
Rat glioma Cells.” Molecular Pharmacology; June 24, 2004
Jiang, D.J. e. al. “ Pharmacological
effects of xanthones as cardiovascular protective agents.”
Cardiovascular Drug Reviews , 2004, 22(2):91-102
Biochem Pharmacol, 2002 Jan
1;63(1):73-9
Evaluation of the antifungal activity
of natural xanthones from Garcinia mangostana and their synthetic
derivatives – J. Nat Prod 1997 May; 60 (5):519-24
Active constituents against HIV-1
protease from Mangosteen- Planta Med 1996 Aug;62(4):381-2
Mangostin inhibits the oxidative
modification of human low density lipoprotein- Free radic Res. 1995
Aug.:23(2):175-84
Antiproliferation, antioxidation and
induction of apoptosis by Garcinia mangostana on SKBR3 human breast
cancer cell line J.Ethnopharmacol, 2004 Jan:90(1):161-6
Induction of apoptosis by xanthones
from mangosteen in human leukemia cell lines
J.Nat Prod. 2003 Aug;55(8):1124-7
These statements have
not been evaluated by the Food and Drug Administration. This
information and product is not intended to diagnose treat, cure or
prevent any disease. It is provided for educational purposes only
and is not intended as medical advice. If you have any concerns you
should consult with an appropriate health professional.
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